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KMID : 0364820120480030175
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Korean Journal of Microbiology
2012 Volume.48 No. 3 p.175 ~ p.179
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Serotype Distribution of Human Respiratory Adenovirus Isolated in Gyeonggi Province
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Lee Hyun-Kyung
Lee Myung-Jin
Moon Su-Kyoung
Kim Woon-Ho
Cho Han-Gil
Yoon Mi-Hye
Lee Jung-Bok
Chung Hyang-Min
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Abstract
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Adenoviruses are an important cause of respiratory tract infections, particularly in infants, young children, and
immuno-compromised patients. In this study, we investigated the characteristics of adenoviruses isolated from
outpatients with acute respiratory illness in Gyeonggi province of South Korea during 2009?2011. Adenoviruses
were detected in 102 of 1,622 (6.3%) specimens by using PCR or real-time PCR with viral specific primers. 76
isolates were obtained from 102 specimens using the A549 cells. Serotypic distributions of isolated adenovirus were
analyzed by sequencing of hexon gene. Six different serotypes were identified, which included adenovirus serotypes
1?6. Adenovirus 3 (n=40, 52.6%) was the predominant serotype. The predominant types of adenovirus every year
were serotypes 1 and 3 in 2009, serotype 3 in 2010, and serotype 5 in 2011, respectively. Adenoviruses 1, 2, 4, 5, and
6 were isolated sporadically throughout the study period. Adenovirus 3 was present both during outbreaks and in
sporadic cases. These results indicate that adenovirus 3 played major causative agent of adenovirus outbreaks in
Gyeonggi province of South Korea during 2009?2011. Continuous surveillance for specific serotypes of adenovirus
that can cause outbreaks is important.
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KEYWORD
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acute respiratory infection, adenoviruses, hexon, serotyping
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